Conditions & Presenting Issues

22 conditions mapped to therapeutic approaches, ranked by evidence

Depression & Mood Disorders

Persistent low mood, loss of interest, fatigue, sleep/appetite disruption, and cognitive changes. Includes major depressive disorder, persis…

79 modalities 14 guideline-recommended
~8% of US adults in any given year; ~20% lifetime
Depressive Disorders / Bipolar Disorders (DSM-5-TR)

Anxiety Disorders

Excessive worry, fear, or avoidance that interferes with daily functioning. Includes generalized anxiety (GAD), panic disorder, social anxie…

66 modalities 2 guideline-recommended
~19% of US adults in any given year; ~31% lifetime
Anxiety Disorders (DSM-5-TR)

PTSD & Acute Trauma

Intrusions, avoidance, negative cognitions/mood, and hyperarousal following exposure to a traumatic event. Includes PTSD and acute stress di…

50 modalities 10 guideline-recommended
~6% lifetime; higher in combat veterans, assault survivors
Trauma- and Stressor-Related Disorders (DSM-5-TR)

Attachment & Relational Patterns

Insecure attachment styles (anxious, avoidant, disorganized) that create recurring difficulties in relationships, emotion regulation, and se…

43 modalities 2 guideline-recommended
~40-50% of adults have insecure attachment
Not a DSM diagnosis; relational patterns underlie many conditions

Complex Trauma / Developmental Trauma

Emotional dysregulation, negative self-concept, and relational difficulties following prolonged or repeated trauma, often in childhood. ICD-…

38 modalities 2 guideline-recommended
Prevalence uncertain; common in clinical populations
Not a separate DSM-5-TR diagnosis; overlaps PTSD, personality disorders

Existential & Meaning-Making Concerns

Questions about purpose, mortality, freedom, isolation, and meaning — particularly during life transitions, terminal illness, or crises. Not…

33 modalities
Universal human concern; heightened during transitions and illness
Not a mental disorder; may overlap adjustment disorders, V/Z codes

Substance Use & Addictions

Compulsive use despite consequences, tolerance, withdrawal, and functional impairment. Includes alcohol, opioids, stimulants, cannabis, and …

29 modalities 6 guideline-recommended
~17% for any SUD in past year (US)
Substance-Related and Addictive Disorders (DSM-5-TR)

Personality Disorders

Enduring patterns of inner experience and behavior that deviate from cultural expectations, are pervasive and inflexible, and cause distress…

23 modalities 4 guideline-recommended
~10% general population; ~40-60% of clinical populations
Personality Disorders (DSM-5-TR)

Grief & Loss

Normal and complicated grief following bereavement, other losses, or life transitions. Prolonged grief disorder is now a DSM-5-TR diagnosis.…

23 modalities 2 guideline-recommended
~10% of bereaved develop prolonged grief
Prolonged Grief Disorder (DSM-5-TR, new in TR)

Child & Adolescent Behavioral Problems

Oppositional behavior, aggression, conduct problems, and emotional dysregulation in youth. Includes ODD, conduct disorder, and ADHD-related …

20 modalities 8 guideline-recommended
~8% for ODD; ~4% for conduct disorder
Disruptive, Impulse-Control, and Conduct Disorders (DSM-5-TR)

Chronic Pain & Somatic Symptoms

Persistent pain or somatic symptoms with significant psychological components. Includes somatic symptom disorder, illness anxiety, and chron…

20 modalities 2 guideline-recommended
~20% of adults have chronic pain; ~5-7% high-impact chronic pain
Somatic Symptom and Related Disorders (DSM-5-TR)

Couples & Relationship Distress

Communication breakdown, conflict patterns, emotional disconnection, infidelity, and attachment injuries. EFT, Gottman Method, and IBCT have…

16 modalities 2 guideline-recommended
~40-50% of marriages end in divorce; relationship distress extremely common
Not a mental disorder; V/Z codes in DSM-5-TR

Eating Disorders

Severe disturbances in eating behaviors and related thoughts/emotions. Includes anorexia nervosa, bulimia nervosa, binge eating disorder, an…

13 modalities 2 guideline-recommended
~5% lifetime; highest mortality of any mental disorder (anorexia)
Feeding and Eating Disorders (DSM-5-TR)

Dissociative Disorders

Disruptions in consciousness, memory, identity, or perception. Includes DID, depersonalization/derealization, and dissociative amnesia. Ofte…

10 modalities 1 guideline-recommended
~2% for pathological dissociation; higher in trauma populations
Dissociative Disorders (DSM-5-TR)

Suicidality & Self-Harm

Suicidal ideation, planning, attempts, and non-suicidal self-injury. Not a diagnosis itself but a clinical priority cutting across many cond…

10 modalities 4 guideline-recommended
~5% of adults have serious suicidal thoughts in a given year (US)
Cross-cutting; suicidal behavior disorder proposed in DSM-5-TR Section III

Perinatal Mental Health

Mental health difficulties arising during pregnancy or the first year postpartum. Includes perinatal depression, perinatal anxiety, postpart…

7 modalities
~15-20% of birthing parents; higher in low-income populations and those with prior mental health history
Peripartum Onset Specifier across multiple disorder categories (DSM-5-TR)

OCD & Related Disorders

Intrusive obsessions and/or compulsive behaviors. Includes OCD, body dysmorphic disorder, hoarding, trichotillomania, and excoriation. ERP i…

6 modalities 2 guideline-recommended
~2-3% lifetime for OCD
Obsessive-Compulsive and Related Disorders (DSM-5-TR)

Psychosis & Schizophrenia Spectrum

Hallucinations, delusions, disorganized thinking/behavior, and negative symptoms. Psychotherapy is typically adjunct to medication. CBTp has…

6 modalities 2 guideline-recommended
~1% lifetime for schizophrenia; ~3% for psychotic experiences
Schizophrenia Spectrum and Other Psychotic Disorders (DSM-5-TR)

Sexual Dysfunction & Intimacy Concerns

Difficulties with sexual desire, arousal, orgasm, pain during sex, or overall sexual satisfaction that cause personal distress or interperso…

6 modalities
~30-40% of adults report some form of sexual difficulty; prevalence varies by specific condition, age, and gender
Sexual Dysfunctions (DSM-5-TR)

Insomnia & Sleep Disorders

Persistent difficulty initiating or maintaining sleep, early morning awakening, or nonrestorative sleep that impairs daytime functioning. In…

5 modalities
~10-15% chronic insomnia; ~30% intermittent insomnia symptoms in US adults
Sleep-Wake Disorders (DSM-5-TR)

Adult ADHD

Persistent patterns of inattention, hyperactivity, and/or impulsivity that began in childhood and continue to cause functional impairment in…

5 modalities
~4-5% of US adults; ~2.5% worldwide; widely considered underdiagnosed
Attention-Deficit/Hyperactivity Disorder (DSM-5-TR)

Autism & Neurodevelopmental

Differences in social communication, sensory processing, and behavioral flexibility. Therapeutic approaches range from behavioral (ABA) to d…

2 modalities 1 guideline-recommended
~2.8% of children (CDC, 2023)
Neurodevelopmental Disorders (DSM-5-TR)